Among 64 NSCLC tissues with low circPTK2 expression, 49 tumors (76.6%) showed low TIF1γ expression (Fig. 6j and k; Additional file 10: Table S3); In contrast, of 7 NSCLC tissues with high circPTK2 expression, 4 tumors (57.1%) presented high TIF1γ expression (Fig. 6j and k; Additional file 10: Table S3). Here, TRIM33 is linked to non-small cell lung carcinoma.