LIF and demyelinating disease: Studies in LIF knock-out mice and exogenous LIF administration have highlighted its protective action in many models of demyelination (Nicola & Babon, 2015; Davis & Pennypacker, 2018; Slaets et al., 2010; Emery et al., 2006; Marriott et al., 2008), suggesting the possible therapeutic use of LIF and LIF inducers in demyelinating diseases, including MS (Slaets et al., 2010; Vela et al., 2016; Metcalfe, 2018).