TLR2 and myeloid sarcoma: TLR2 is upregulated in experimental models of MS and in MS demyelinating lesions, where it is also expressed by OLs (Sloane et al., 2010; Zekki et al., 2002; Esser et al., 2018); TLR2 activation inhibits OL maturation, an effect not shared by all TLRs (Sloane et al., 2010).