When a mutationally activated form of Rac1 (Rac1G12V) was introduced into ovarian tumor cells with an epithelial phenotype, cells displayed morphologic characteristics of EMT including down-regulation of the epithelial marker E-cadherin, up-regulation of the mesenchymal marker vimentin, and increased invasive capacity [46]. The gene discussed is RAC1; the disease is ovarian neoplasm.