RAC1 and ovarian neoplasm: LPA activation of Rac1 has also been reported to be dependent on a Src/p130Cas pathway for ovarian cell migration [87] and the Rac1 GEF βPIX was necessary for LPA-induced invadopodia formation [88] although βPIX knock-down did not disrupt LPA-stimulated migration in certain ovarian tumor cell lines [86].