Taking into account the use of tannic acid modified AgNPs as microbicides, we can therefore hypothesize that upon treatment of the primary infection, the HSV-2 virions treated with tannic acid modified silver nanoparticles may be more effectively internalized by migratory DCs, activate DCs to present and prime CD4+ and CD8+ T cells, and also to effectively activate B cells. Here, CD4 is linked to infection.