FCGR2B and fatty liver disease: Considering that the liver tissue is composed of hepatocytes, hepatic stellate cells, Kupffer cells, and sinusoidal endothelial cells, which are all reported to contribute to the development of fatty liver [19], mice with FcγRIIb−/− specific to hepatocytes are the best choice to verify if the mechanism identified in HepG2 exists and acts the same way in vivo.