The association of RASSF1A promoter methylation with PR status parallels previous reports [43] and higher RARβ2 methylation in node-positive BrC is in line with previous findings in sentinel lymph node metastasis [44] and the correlation between primary BrC and lymph node metastasis tissues [45]. Here, RASSF1 is linked to metastatic malignant neoplasm in the lymph nodes.