Since APC, FOXA1 and RASSF1A were biomarkers common to BrC, CRC and LC, they were further tested as gene panel for cancer detection (designated “PanCancer”), whereas RARβ2, SCGB3A1, SEPT9 and SOX17 were considered a gene panel for discrimination of primary cancer localization (“CancerType” panel). The gene discussed is SEPTIN9; the disease is laryngotracheoesophageal cleft.