As for CRC, the significantly higher APC, FOXA1, RARβ2, RASSF1A, SCGB3A1, SEPT9 and SOX17 methylation levels in cancer patients are in line with previous publications [16,27,36,37,38,39], although divergent results have been reported for MGMT [16,27]. This evidence concerns the gene RASSF1 and colorectal carcinoma.