SHOX2 and colorectal carcinoma: In CRC patients, APC, FOXA1, RARβ2, RASSF1A, SCGB3A1, SEPT9 and SOX17 methylation levels were significantly higher than in controls (p = 0.005, p < 0.0001, p = 0.009, p = 0.012, p = 0.003, p = 0.001 and p = 0.007, respectively) (Figure 1, Supplementary Table S1), although no differences were apparent for MGMT and SHOX2 methylation levels.