When Nrf1α was knocked out by Talens-mediated gene editing in the liver cancer HepG2 cells [38], at least 16 bZIP factors, such as Bach2, MafK, MafF, Jun, FosB, Fra1, ATF3, ATF4, NRL, HLF, TEF, CREB5, CEBPE, E4BP4, BATF3, and CREM were up-regulated significantly (with >+1 of the Log2-based RPKM values being calculated) (Figure 4b,d). The gene discussed is CREM; the disease is liver cancer.