VEGFA and malignant glioma: Nelfinavir has been shown to reduce Akt phosphorylation and improve radio- and chemosensitization in GBM cells [17], to cause malignant glioma death through the induction of endoplasmic reticulum stress response both in vitro and in vivo [18] and to inhibit vascular endothelial growth factor (VEGF)/hypoxia-inducible factor (HIF)-1alpha expression and angiogenesis in GBM cells [19].