While human and mouse resistin only share a 59% homology, and it currently appears there are differences in regulation and function, human resistin is involved in inflammation-induced insulin resistance in the liver and skeletal muscle and may also be implicated in cardiovascular disease [53], though the influence of obesity on resistin levels is unclear [54,55,56]. The gene discussed is RETN; the disease is obesity due to melanocortin 4 receptor deficiency.