Specifically, HMGB1 secreted from dying cells interacts with TLR4 on the surface of DCs, triggering the MyD88-dependent signalling cascade, leading to inhibition of the fusion of phagosomes and lysosomes, ultimately facilitating tumour antigen processing, antigen presentation, and stimulation of the adaptive immune response [87,99]. This evidence concerns the gene HMGB1 and neoplasm.