PITX2 and breast carcinoma: With respect to the involvement of RGS proteins in the dynamics of DDR responses, early research indicated that disruptions to RGS protein (RGS16, RGSL1/RGSL2 (RGS-like proteins 1/2)) expression/functions were mediated in human breast carcinomas through DNA fragility within the HPC1 region in chromosome 1 [216].