CD163 and rheumatic heart disease: Interestingly, the strongest correlation was with CD163 for M2 macrophages (pro-resolution profile), which correspond to our recent finding that M2 macrophages are crucially associated with cardiac remodelling in dilated cardiomyopathy.[26] Further, increased numbers of DCs and other inflammatory cells in LA were associated with ECM remodelling, which may affect the persistent inflammatory process in RHD.