KLF5 and Reoviridae infectious disease: Transcripts that were up-regulated and stabilized following reovirus infection included SMAD 1, 2, 6 &7, Tgif, c-Myc, CITED2 and KLF5, which encode components of the SSN that control transcription of genes that regulate apoptosis and cell growth [47, 50, 51, 53, 54].