A central role of ERK1/2, rather than AKT, in EGF-induced EMT induction conforms with earlier reporting [50–52,99] but is in contradiction to the published role of AKT in prostate cancer cell lines [53], nasopharynx carcinoma [79], and mammary MCF7 cells [100]. The gene discussed is MAPK3; the disease is Familial prostate cancer.