GSDMC and osteoarthritis: Although the specific role of GSDMC in lumbar disc herniation and/or sciatica is unclear, GSDMC is associated with differential methylation patterns in osteoarthritis-related cartilage and subchondral bone cartilage, [49, 50] consistent with our findings that variants in LD with rs4384683 were located in potential regulatory regions in chondrocytes and osteoblasts.