GSDMC and osteoarthritis: Our examination of univariate cross-phenotypic genetic associations for CBP-associated variants at CCDC26/GSDMC also suggest pleiotropy with radiographic hip OA for rs6470763.[29] Taken together, these data suggest interconnections between variants at CCDC26/GSDMC and CBP involving cartilage, osteoarthritis, and/or lumbar disc degeneration.