In summary, this meta-analysis of GWAS of CBP identified novel genetic associations with CBP at SOX5, CCDC26/GSDMC, and DCC. Analysis of data from other GWAS and functional genomics experiments suggest possible pleiotropic effects of these loci on other traits including cartilage, osteoarthritis, lumbar disc degeneration, depression, and height/vertebral development, and possible causal effects on CBP mediated through height. The gene discussed is SOX5; the disease is lumbar disk degenerative disorder.