In line with these findings, earlier studies divulged that cilostazol possesses an anti-apoptotic effect via enhancing the phosphorylation/activation of CREB and increasing the anti-apoptotic Bcl-2 in cerebral ischemia model [17,43] and in the white matter region after cerebral hypoperfusion [18]. The gene discussed is CREB1; the disease is Cerebral ischemia.