In support of this, previous studies have shown that KDACi increased IL-1β-induced miR-146a-5p expression in osteoarthritis fibroblast-like synoviocytes [48] and upregulated basal as well as lipopolysaccharide (LPS)-stimulated miR-146a-5p expression in macrophages isolated from mice [49]. This evidence concerns the gene IL1B and osteoarthritis.