Although inhibition of TNKS activity has been shown to block Apc mutant colorectal cancer development [53, 54], we found that the organoids derived from the polys of Villin-Cre;Apc+/fl mice showed normal cell proliferation and activation of Wnt/β-catenin signaling in the presence of XAV939. This evidence concerns the gene TNKS and colorectal cancer.