Aβ aggregation was found to be in association with neuronal and astrocytic Ca2+ disturbances.79, 80 Many studies have provided evidence of the increased level and/or activity of BACE1 upon a variety of assaults like oxidative stress,83 hypoxia,84 ischemia85, and TBI.86 Likewise, the level and activity of BACE1 were reported to be upregulated in AD brain,87, 88 and this might initiate or at least worsen AD progression. The gene discussed is BACE1; the disease is Alzheimer disease.