Proband (IV‐11) was screened for a panel of 14 genes (APC, AXIN2, EPCAM, MLH1, MLH3, MSH2, MSH6, MUTYH, PMS1, PMS2, STK11, PTEN, SMAD4, and BMPR1A) related with CRC by targeted next‐generation sequencing (NGS). The gene discussed is BMPR1A; the disease is colorectal carcinoma.