Proband (IV‐11) was screened for a panel of 14 genes (APC, AXIN2, EPCAM, MLH1, MLH3, MSH2, MSH6, MUTYH, PMS1, PMS2, STK11, PTEN, SMAD4, and BMPR1A) related with CRC by targeted next‐generation sequencing (NGS). The gene discussed is MSH6; the disease is colorectal carcinoma.