Proband (IV‐11) was screened for a panel of 14 genes (APC, AXIN2, EPCAM, MLH1, MLH3, MSH2, MSH6, MUTYH, PMS1, PMS2, STK11, PTEN, SMAD4, and BMPR1A) related with CRC by targeted next‐generation sequencing (NGS). Here, MSH2 is linked to colorectal carcinoma.