Proband (IV‐11) was screened for a panel of 14 genes (APC, AXIN2, EPCAM, MLH1, MLH3, MSH2, MSH6, MUTYH, PMS1, PMS2, STK11, PTEN, SMAD4, and BMPR1A) related with CRC by targeted next‐generation sequencing (NGS). This evidence concerns the gene EPCAM and colorectal carcinoma.