The EMT involves the conversion of epithelial cells to migratory and invasive cells, and the activation of the EMT is closely associated with the motility and invasiveness of GC cells.24, 25FZD7, CDH2, TGFB1, SPARC, ITGA5, and ZWB1 are associated with the EMT and malignant cell function, indicating that SUSD2 may play a role in the WNT pathway and the EMT.23, 26, 27, 28, 29, 30 Therefore, SUSD2 may serve as a therapeutic target for inhibiting inappropriate WNT signaling or induction of the EMT. This evidence concerns the gene SPARC and gastric cancer.