For example, SUSD2 exhibits tumor suppressor activity in high‐grade serous ovarian carcinomas17 and may function as a tumor suppressor in renal cell carcinoma and lung cancer.18 Low levels of SUSD2 expression correlate with the aggressive behavior of non‐small cell lung cancer cells.19SUSD2 is expressed in endometrial carcinoma cells, and suppressing its expression following treatment with TGFβ or a specific siRNA increases apoptosis and senescence. The gene discussed is SUSD2; the disease is hereditary clear cell renal cell carcinoma.