SUSD2 and breast carcinoma: For example, SUSD2 increases the invasiveness of breast cancer cells and may act as a component of the mechanism of immune evasion through induction of apoptosis of the Jurkat T cell line.14SUSD2 recruits macrophages into the tumor microenvironment, and promotes M2 polarization, indicating that inhibiting the function of SUSD2 may serve as an effective therapy for patients with breast cancer.16