FZD7 and hematologic disorder: Specifically, the evolutionarily conserved WNT signaling pathway controls intercellular interactions during embryogenesis, and dysfunction of this pathway is implicated in a spectrum of human diseases, particularly solid and hematologic malignancies.21 Thus, WNT signaling may serve as a target of cancer therapy.22 Fzd7 is the WNT receptor most commonly upregulated in diverse cancers and plays a significant role in stem cell biology and cancer development and progression.