AHNAK is a desmosomal connexin, located in chromosome 11: 62433542‐62556235, encoding 700 kDa protein, and is expressed in all kinds of cancer cells.18, 19 It has been reported that low expression of AHNAK can effectively inhibit breast cancer cell invasion and proliferation as a tumor suppressor.20, 21 In glioma, AHNAK can depress tumor development and serve as a biomarker of tumor prognosis.22 Moreover, low expression of AHNAK in melanoma indicates poor prognosis.23 Nevertheless, the role of AHNAK in the development and prognosis of liver cancer remains unclear. Here, AHNAK is linked to melanoma.