We have validated this model in lung cancer cell lines, demonstrating that once STAT3 is activated by upstream epidermal growth factor stimulation, PIAS3 is rapidly translocated from the cytoplasm into the nucleus and associates with p‐STAT3 to form a complex and downregulate STAT3 transcriptional activity (Dabir et al., 2009). This evidence concerns the gene PIAS3 and lung cancer.