We and others have also reported that restoring PIAS3 expression by curcumin and other natural compounds, such as ascochlorin and brassinin, have anti‐tumor effects, indicating that PIAS3 restoration can be a potential therapeutic strategy for cancer treatment (Dabir et al., 2014; Dai et al., 2015; Lee et al., 2015; Saydmohammed et al., 2010). This evidence concerns the gene PIAS3 and cancer.