PIAS3 and cancer: Furthermore, we and others have shown that downregulated PIAS3 expression in tumors is correlated with hyper‐active STAT3 signaling, increased proliferation, survival, and migration in cancer cell lines and poor patient overall survival in the clinic (Abbas et al., 2015; Brantley et al., 2008; Dabir et al., 2014), suggesting impaired PIAS3 regulation of activated STAT3 in these cancers.