The study was designed: (a) in breast cancer to assess the effect of chemotherapy on [18F]ICMT-11 uptake correlated with blood cytokeratin-18 assessment and biopsy-derived caspase-3/7 tissue expression within 24 h of the first dose of neoadjuvant FEC-T treatment, and (b) in lung cancer to measure the longitudinal effect of first-line chemotherapy on [18F]ICMT-11 correlated with diffusion-weighted and dynamic contrast-enhanced magnetic resonance imaging (DW- and DCE-MRI) at each time point; notably, the latter was more difficult to recruit to, as a result only descriptive data are presented. This evidence concerns the gene CASP3 and breast cancer.