Taken together, although we cannot rule out the role of several IFNγ producing invariant T cells in the liver infection model, the deletion of Runx3 in some PLZF expression cells other than ILCs is consistent with the conclusion that Runx3 mediates resistance to intracellular bacterial infection by promoting IL12 signaling in Group1 ILCs and NCR+ILC3s. This evidence concerns the gene IFNG and bacterial infectious disease.