In this sense, T-cell integrins and their cognate ligands expressed on target cells, mainly lymphocyte-function-associated antigen-1 (LFA-1)/intercellular adhesion molecule-1 (ICAM-1) and CD103/E-cadherin play a relevant role in the interactions between cytotoxic T lymphocytes and tumor cells (17, 18). The gene discussed is ICAM1; the disease is neoplasm.