For instance, in melanoma CD103+ CD69+ TILs were PD-1+ and LAG-3+ but negative for CTLA-4 (36); in NSCLC CD103+ TILs expressed PD-1 and TIM-3 but with negligible CTLA-4 expression (37) and in HGSC CD103+ TILs did not express TIM-3, CTLA-4 or LAG-3 (50). This evidence concerns the gene HAVCR2 and melanoma.