HMGB1 and schistosomiasis: To further confirm the role of HMGB1 in the development of schistosomiasis, we chose to establish a survival curve of infected animals, but we treated the animals only with DIC (and not GZR) due to its ability to inhibit HMGB1 secretion but also because of its novelty in vivo experiments [the anti-HMGB1 activity of GZR has been previously tested in animals with different inflammatory diseases (54)].