Since GZR- or DIC-mediated inhibition of HMGB1 culminated in the downregulation of IL-13 (Figure 4G), a cytokine known to be involved in liver fibrosis regulation, we decided to investigate the role of HMGB1 in the pro-fibrotic processes of murine schistosomiasis. The gene discussed is HMGB1; the disease is schistosomiasis.