Therefore, we next examined the relationship between TFH and TFR within HIV infected tonsils, defining TFR as CD4+CXCR5+CD25+CD127low cells that are enriched for the TREG transcriptional factor FoxP3 (30) (Figure 4A), and having found that CD25 expression is not affect by HIV infection (Figure S3A). Here, FOXP3 is linked to HIV infectious disease.