In man, the same research group also showed that haploinsufficiency at the PRKAR1A locus found in ~75% of patients suffering from Carney complex (CNC), in addition to suffer from spotty skin pigmentation, cardiac and cutaneous myxomas, and endocrine tumors such as micronodular adrenocortical hyperplasia (MAH), these proteins also had reduced fertility due to unregulated C subunit activity in male germ cells (201). This evidence concerns the gene PRKAR1A and Carney complex.