Furthermore, GH intervention in children diagnosed with Prader-Willi syndrome retarded the progression of obesity, reduced blood pressure, and improved the metabolic profile but failed to abolish hyperphagia (23); which is in support of the notion that the association between low GH level and obesity can be ascribed to the reduction of AG in obese individuals (24). The gene discussed is GH1; the disease is obesity due to melanocortin 4 receptor deficiency.