While a decreased total ghrelin/obestatin ratio in women with obesity has been previously reported (16), to our best understanding, we have provided the first piece of evidence that the presentation of both hypertension and central obesity is associated with decreased UnAG/obestatin, AG/obestatin and total ghrelin/obestatin ratios. This evidence concerns the gene GHRL and obesity due to melanocortin 4 receptor deficiency.