GHRL and hypertensive disorder: Nonetheless, interaction effect between hypertension and central obesity was observed with obestatin and the ratios of the two ghrelin forms to obestatin, suggesting that the obestatin and the ratios of the two ghrelin forms to obestatin were not augmented or even dampened in response to the co-manifestation of hypertension and central obesity compared with the presence of hypertension or central obesity alone.