EPO and amyotrophic lateral sclerosis: Erythropoietin (EPO) has been shown to have neuroprotective properties in several animal models (16), including those of spinal cord injury (17), adult focal ischemia (18), neonatal hypoxia-ischemia (19), neonatal white matter injury (20, 21), traumatic brain injury (22), chronic autoimmune encephalomyelitis (23), and amyotrophic lateral sclerosis (24) as well as neonatal brain injury (25, 26).