Recently, SGLT1 upregulation was causally linked to PRKAG2 cardiomyopathy that is caused by mutations in the gene encoding the γ2 subunit of AMP-activated protein kinase (Banerjee et al., 2010) and cardiac-specific SGLT1 deletion attenuated the cardiomyopathy (Ramratnam et al., 2014). This evidence concerns the gene SLC5A1 and cardiomyopathy.