SLC5A3 and Hyperglycemia: Van Steenbergen et al. (2017) found that hyperglycemia stimulates the production of reactive oxygen species in the heart through activation of NADPH oxidase and this mechanism is prevented in myocytes from mice with genetic deletion of the sodium-myoinositol cotransporter-1 (SMIT1). This finding suggests that SMIT1 is activated by high glucose, which may also contribute to the [Na+]i rise in diabetic hearts.