MAPT and Alzheimer disease: In addition to Aβ and phospho-tau, alpha-synuclein (α-Syn) ubiquitin, and apolipoprotein E acculate in muscle, highlighting common pathological parallels between AD and IBM (Albrecht and Bilbao, 1993; Askanas et al., 1994; Mirabella et al., 1996; Askanas and Engel, 2006).