In obesity, excess adipose tissue leads to hyperleptinemia and leptin resistance as well as increased production of pro-inflammatory cytokines (Maffei et al., 1995; Marsh et al., 1999; Schwartz et al., 2000; Fantuzzi, 2005) resulting in decreases in whole body insulin sensitivity and disruption in appetite control and regulation of food intake (Hellstrom, 2013). This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.