Its expression is also increased in microglia accompanied by osteopontin and vascular endothelial growth factor (VEGF), concomitantly with low expression of TNFα, IL-6, brain-derived neurotrophic factor (BDNF) and arginase-1 from ALS rat model SOD1 (G93A) (Nikodemova et al., 2014). This evidence concerns the gene BDNF and amyotrophic lateral sclerosis.