Activation of the Wnt pathway is known to support neuronal survival, and induction of the Wnt inhibitor, Dkk-1, contributes to neuronal death in experimental animal models of cerebrovascular disorders (Cappuccio et al., 2005; Zhang et al., 2008; Mastroiacovo et al., 2009; He et al., 2016; Li et al., 2017), AD (Caricasole et al., 2004; Wang et al., 2016), temporal lobe epilepsy (Busceti et al., 2007), and stress-related disorders (Matrisciano et al., 2011). The gene discussed is DKK1; the disease is cerebrovascular disorder.