Dkk3 behaves as an oncosuppressor protein by inducing apoptotic death in a variety of cancers (Hoang et al., 2004; Hsieh et al., 2004; Ueno et al., 2011; Dellinger et al., 2012; Veeck and Dahl, 2012; Yang et al., 2012; Eskander et al., 2016; Lorsy et al., 2016; Sawahara et al., 2016), although it might favor cancer cell spreading by promoting angiogenesis (Untergasser et al., 2008; Zitt et al., 2008). This evidence concerns the gene DKK3 and cancer.