Several pathway analyses of AD GWAS dataset have identified some immune pathways in AD, including Natural killer cell mediated cytotoxicity (hsa04650), Antigen processing and presentation (hsa04612), retinoic acid-inducible gene-I (RIG-I)-like receptor signaling (hsa04622), asthma (hsa05310), hematopoietic cell lineage (hsa04640), graft-versus-host disease (hsa05332), allograft rejection (hsa05330), autoimmune thyroid disease (hsa05320), and type I diabetes mellitus (hsa04940) (Hong et al., 2010; Jones et al., 2010; Lambert et al., 2010; Liu et al., 2012). Here, RIGI is linked to autoimmune thyroid disease.