In the patients with type-I diabetes having HLA-DRB1*4 allele associated rheumatoid arthritis, the Type-II collagen antigenicity is increased significantly by oxidative PTMs while its increase is less in type-I diabetes patients without HLA-DRB1*4 allele associated rheumatoid arthritis [14]. Here, HLA-DRB1 is linked to type 1 diabetes mellitus.