MiRNAs regulated by CpG probes localized in island regions were involved in multiple pathways related to cancer (transcriptional misregulation in cancer, prostate, lung and endometrial cancer pathway, among others), adherent junctions, oestrogen signalling pathways, etc. For deregulated miRNAs in BCVY whose methylation was regulated by open sea regions, we identified pathways related to cancer as previously observed for island miRNAs and, moreover, they were implicated in tumour-necrosis signalling pathways, extracellular matrix-receptor interaction and prolactin signalling pathways. The gene discussed is PRL; the disease is endometrial cancer.