OFD1 and ciliopathy: Given that all three genes (Talpid3, Ofd1, and C2cd3) have been implicated in ciliopathies and that several inter-related sets of defects result from the loss of each gene, these findings point to a potentially important and intimate relationship between Talpid3, OFD1, and C2CD3 in assembling an essential functional complex at basal body distal ends, defects in which lead to human ciliopathies.