NKX2-1 and breast cancer: This role for NKX2-1-AS1 appears to be mediated through its suppression of the transcription of several genes involved in cell adhesion, including PTPN1, which promotes migration and invasion in breast cancer cells31 and in epidermal dendritic cells32 and dephosphorylates β-catenin, adding to the adhesive properties of the cells by activation of cadherin44, and CLDN1, which encodes a tight junction component necessary for cell migration in skin wound healing and in human lung carcinoma cells45,46.