Recent findings point to a potential role for NKX2-1-AS1, a long non-coding RNA (lncRNA) mapped to this region, as a regulator of lung tumor cell properties: its selective expression in cell lines of lung and thyroid origin22; its increased expression in lung adenocarcinomas11,21,23; and its close proximity to the transcription factor NKX2-1 (thyroid-transcription factor 1, TTF1, NKX2.1), which is already known to contribute to lung cancer progression35. Here, TTF1 is linked to lung carcinoma.