Finally, it remains to be seen how the bidentate complex may affect deubiquitination of other PR-DUB substrates—for instance BAP1 has been proposed to remove ubiquitin from its own C-terminal tail, as well as Host Cell Factor-1 (HCF-1; which binds within the BAP1-specific insert) and Ube2O29,30,34, both of which are highly relevant to the role of the PR-DUB in cancers. This evidence concerns the gene ZUP1 and cancer.