We noted recurring missense mutations relevant to the ‘NEF’ loop in cBioPortal: Glu330 in ASXL2 is mutated in breast, bladder, and urothelial tumours; His315 in ASXL1 in colon, colorectal, lung cancer, and melanoma patient samples (Supplementary Table 3). The gene discussed is ASXL1; the disease is lung carcinoma.