Mutations in BAP1 are responsible for BAP1 tumour predisposition syndrome (BAP1-TPDS; OMIM number: 614327), which drives development of mesothelioma, melanoma, and other neoplasms; sporadic mutations in BAP1 and ASXL1–3 also frequently occur across various cancer types10–13. Here, ASXL1 is linked to cancer.