Recently, the mitogen-activated protein kinase (MAPK) pathway has been shown to result in an increased mitochondrial fragmentation and promote tumor growth and chemoresistance via the phosphorylation of the mitochondrial protein Drp1 at serine 616 by extracellular signal-regulated kinase 2(ERK 2) in several cancers11–14. This evidence concerns the gene MAPK1 and neoplasm.