Mass spectrometry analysis of the FLAG immunoprecipitates identified a significant enrichment of viral ANK proteins CPXV 016 (the homologue of ECTV 010) and CPXV 019 in the Cul-2 and Cul-2.NTD pulldowns compared to the EV condition (Data Set S2), demonstrating that these proteins interact with Cul-2 during virus infection. Here, CUL2 is linked to viral infectious disease.