CDX2 and neoplasm: In cohort 1, there was a significant correlation between reduced CDX2 expression and female gender (p = 0.0338); more advanced pT classification (p = 0.0068), lymph node metastasis (p = 0.0167), and distant metastasis (p = 0.0123); and higher tumor grade (p = 0.0163) (Table 1).