Similar correlations could be found for cohort 2 with significant associations between reduced CDX2 and histological subtype (p = 0.009), right-sided tumor location (p = 0.0135), more advance pT stage (p = 0.0002), distant metastasis (p = 0.0337), higher tumor grade (p = 0.0004), lymphatic vessel invasion (p = 0.00136), and a trend to venous vessel invasion (p = 0.0706). Here, CDX2 is linked to neoplasm.