In contrast, TS levels were higher after simultaneous exposure to FTD (1.0 μM or 4.0 μM) and regorafenib (10.0 μM) for 24 h and sequential exposure to regorafenib (10.0 μM) for 24 h followed by FTD (1.0 μM or 4.0 μM) for 24 h than those after treatment with regorafenib alone. Here, TYMS is linked to frontotemporal dementia.