IGF1-treated DLD-1 cancer cells were subcutaneously transplanted into NOD/SCID mice, and the tumor-bearing mice were then divided into four groups: sham control, DB (5 mg/kg, 5 times/week), 5-FU (25 mg/kg, 2 times/week), and the combination of DB and 5-FU. The gene discussed is IGF1; the disease is neoplasm.