Of these four, three proteins had no apparent connection to the pathogenesis of asthma: Foxf2 has been shown to play a role in embryogenesis [23], in particular in the development of gut [24] and secondary palate [25], HNF1A is involved in control of liver-specific gene expression [26] and in glucose metabolism [27], and E4F1 is necessary for the proliferation and survival of embryonic, stem, and cancer cells [28,29,30]. The gene discussed is E4F1; the disease is cancer.