BAX and cancer: Among the specific target genes of NF-κB involved in cancer, the major ones are caspase-8 inhibitor FLIP, the inhibitor of apoptosis proteins c-IAP1/2 and XIAP, B-cell lymphoma 2 (Bcl-2), Bcl-extralarge (Bcl-xL), Bax (bcl-2-like protein 4), vascular-endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), IL-8, matrix metalloproteinase-9 (MMP-9), selectins and integrins [66] (Table 1).