TMPRSS2 and posterior cortical atrophy: Among the specific target genes of AR involved in PCa progression, the most important ones are PSA [87], fibroblast growth factor 8 (FGF8) [88], cyclin dependent kinase 1 (Cdk1), Cdk2 [89], prostate transmembrane protein androgen induced 1 (PMEPA1) [90], transmembrane serine protease 2 (TMPRSS2) [91] and FK506 binding protein 5 (FKBP5) [92] (Table 1).