The compound, 3,3-diindolylmethane (DIM) was shown to inhibit cellular proliferation and induce apoptosis in androgen dependent LNCaP and androgen independent C4-2B PCa cell lines by disrupting the potential crosstalk between Akt, NF-κB and AR through significant inhibition of NF-κB DNA binding activity, Akt activation as well as AR phosphorylation and the expression of AR and PSA [132]. This evidence concerns the gene NFKB1 and posterior cortical atrophy.