IGHE and onchocerciasis: In an effort towards the design of an antibody-capture test for monitoring onchocerciasis control programs and to further investigate the observations reported above on the OVS and ITS groups (Fig 5) where similar total IgG but different IgE responses were observed, Ov58GPCR-ECD was characterized with respect to chemotherapy treatment, targeting total IgG, IgG subclasses and IgE.